When it comes to our health, we often hear that genetics plays a significant role. However, in reality, genetics only plays a small part in determining our overall health. There are a few aspects where genetics does have an impact, but it’s crucial to consider the interplay between your genes and epigenetics.
Genetics refers to the proteins and genes you inherit. These proteins are present in everyone, but some may be turned on while others are turned off. This availability of proteins determines various genetic traits like eye color, hair color, and skin tone. However, when it comes to heart disease, the situation is much more complex.
Heart disease is influenced by both genetics and epigenetics. Genetics refers to the proteins and genes that are available to you, while epigenetics refers to the factors outside of your genes that affect their expression. Essentially, epigenetics determines how your genes are turned on or off, and your lifestyle choices can greatly impact this process.
Just like you don’t consciously think about your blood pressure or heart rate, your genetics are continuously being regulated without your awareness. But certain factors, such as stress, can affect gene expression. For example, when you experience a traumatic memory, your body responds by turning on genes that produce stress hormones like adrenaline and norepinephrine. This process influences your heart rate and other bodily responses.
Heart disease is also influenced by lifestyle factors that affect gene expression. When you consume sugar or fat, different genes are activated, leading to the production of specific hormones like insulin and glucagon. Stress is another significant factor that turns on genes related to stress hormone production, which can suppress your immune system and impact the health of your arteries.
Epigenetics and genetics work together to determine your susceptibility to heart disease. Some individuals naturally have a calmer disposition, while others are more prone to stress and producing stress hormones. The latter group tends to have a higher risk of heart disease, showcasing the interplay between genetics and epigenetics.
However, there is one genetic factor that can be tested for and affects heart disease risk directly: lipoprotein(a) or LPA. LPA is a lipoprotein that interferes with clot removal, leading to the formation of larger clots in the arteries. When biopsies are performed on atherosclerotic plaques, they often reveal layers upon layers of clot material, narrowing the arteries and restricting blood flow. Testing for LPA can provide valuable information about your heart disease risk.
Although there are ongoing efforts by pharmaceutical companies to develop drugs that target LPA, these approaches may have limitations. Currently, antibody-based drugs are being explored, but they may have potential side effects and are unlikely to provide a long-term solution.
However, there is a potential natural remedy that may help manage LPA levels: niacin. Niacin, when converted into niacinamide, has been shown to lower LPA levels and aid in the removal of existing atherosclerosis. High-dose niacin can cause temporary discomfort, such as flushing and itching, but it has demonstrated promising results in reducing arterial plaque in some individuals.
In summary, genetics and epigenetics both contribute to the development of heart disease. While genetics determines the proteins and genes available to you, epigenetics regulates their expression. Factors like stress and lifestyle choices can impact gene expression, affecting your heart disease risk. Testing for LPA, a genetic factor that interferes with clot removal, can provide valuable information. Niacin may be a potential natural remedy to manage LPA levels and aid in the reduction of arterial plaque.
Remember, understanding the interplay between genetics and heart disease can help you make informed decisions about your health. Consult with your healthcare provider to discuss appropriate testing and treatment options tailored to your specific needs.
